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More and more people are taking rapamycin<\/a> for longevity<\/a>.<\/p>\n
First, there are reports that rapamycin can cause insulin resistance (R<\/a>). However, this mainly seems to be the case when rapamycin is taken in high doses and for a long-time (due to indirect sequestration of mTOR components that also belong to the mTOR2 complex).<\/p>\n
Furthermore, the \u201chigh glucose\u201d levels induced by rapamycin can also be due to \u201cpseudo\u201d diabetes, caused by the fasting-mimicking effect of rapamycin. I explained this more in detail earlier<\/a>.<\/p>\n
When only rapamycin is taken (so no other, much stronger immunosuppressive drugs), various studies demonstrate that rapamycin can actually improve immune function. For example, rapamycin could reduce the risk of dying from infectious diseases, as I explained earlier<\/a>.<\/p>\n
So which rapamycin doses are taken for longevity?<\/h2>\nMostly, 2 mg to 10 mg of rapamycin is taken, every week or every two weeks.<\/p>\n
Professor Michael Blagosklonny, an expert in rapamycin and longevity, even took a regimen of 20 mg of rapamycin every two weeks.<\/p>\n
Generally, the most often recommended rapamycin dose is between 2 and 8 mg once weekly or every two weeks.<\/p>\n
Mostly, people take 5 to 7 mg weekly.<\/p>\n
Some experts recommend taking \u201crapamycin holidays\u201d. For example, one takes rapamycin (bi)weekly for 3 months. And then takes a break of one month, during which one does not take any rapamycin, and then starts again a 3 month period (R<\/a>). Other people take rapamycin for 3 months, and then take a 3-month break.<\/p>\n
However, there have been longevity or health-focused studies in humans in which rapamycin is given continuously, demonstrating no serious side effects. In one study, a relatively low dose of 1 mg of rapamycin every day in elderly people (to improve immune function) didn\u2019t lead to significant side effects and was shown to be safe (R<\/a>).<\/p>\n
In general, rapamycin has demonstrated to be a reasonably safe drug. Multiple clinical trials show that serious side effects are very low or non-existent. Some studies even show that side effects are higher in the placebo group than in the rapamycin treated group (R<\/a>). In a failed suicide attempt one person took 103 tablets of 1 mg or rapamycin (so 103 mg in one go), with no significant side effects (only elevated cholesterol) (R<\/a>).<\/p>\n
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The post Optimal Rapamycin Dose for Longevity and Anti-Aging<\/a> appeared first on Kris Verburgh<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"